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KMID : 1039220200300030306
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Journal of Korean Society of Occupational and Environmental Hygiene
2020 Volume.30 No. 3 p.306 ~ p.312
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Decreased Plasma Interleukin-18 Levels among Former Dusty Workers with Chronic Obstructive Pulmonary Disease Caused by Exposure to Coal, Silica, or Cadmium Fumes, or Other Factors
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Hwang Joo-Hwan
Kim Seo-Yong
Kim Jung-Ho
Park Sun-Young
Chang Yun-Hee
Hwang Da-Som
Lee Hye-Young
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Abstract
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Objects: The objective of the present study was to evaluate IL-18 levels among former dusty workers who were diagnosed with chronic obstructive pulmonary disease(COPD) caused by exposure to coal, silica, cadmium fumes, or other occupational sources(OCOPD) and compare them with others who were diagnosed with COPD or without COPD.
Methods: Among 402 male former dusty workers who were subject to epidemiology research for work-related COPD and a QuantiFERON-TB Gold In-Tube(QFT-GIT) test for latent tuberculosis infection between January 2015 and December 2016, 96 subjects were selected and included in the present study depending on whether or not there was the remaining QFT-GIT plasma needed for the analysis of cytokines after the QFT-GIT test.
Results: Plasma IL-18 levels in the subjects with OCOPD were significantly lower than those with COPD[234.30(180.53-315.55) vs. 286.36(249.22-342.55) pg/mL, p=0.029] and lower than those without COPD[234.30(180.53-315.55) vs. 261.61(223.17-335.74) pg/mL, p=0.313]. Besides the results of the epidemiology research for work-related COPD, FEV1 %pred, FEV1/FVC, and working duration had an influence on the plasma IL-18 levels among study subjects. Plasma IL-18 levels showed a positive correlation with FEV1 %pred(r=0.151, p=0.156) and FEV1/FVC(r=0.218, p=0.039) adjusted by age, smoking status, and working duration.
Conclusions: Unlike in the previous studies, the present study showed that IL-18 levels in former duty workers with OCOPD were significantly lower than those without COPD. Therefore, IL-18 shows the possibility for supporting a differential diagnosis between COPD and OCOPD.
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KEYWORD
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chronic obstructive pulmonary disease, dusty worker, interleukin-18, occupational chronic obstructive pulmonary disease
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